paclitaxel · Medicine question

Why is combining paclitaxel with rifampicin not recommended?

iatroX medicinesPublished 8 November 2026

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Combining paclitaxel with rifampicin is not recommended because rifampicin induces CYP2C8 or CYP3A4, potentially lowering paclitaxel exposure and compromising its efficacy.

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Paclitaxel 6 mg/ml concentrate for solution for infusionHospira UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 18Document updated 23 March 2026

Sources checked 8 November 2026

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