paclitaxel · Medicine question

How does paclitaxel interfere with microtubule function?

iatroX medicinesPublished 8 November 2026

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Paclitaxel promotes microtubule assembly from tubulin dimers and prevents depolymerisation, blocking the dynamic reorganisation needed for interphase and mitosis, while inducing abnormal microtubule bundles and multiple asters during mitosis.

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Paclitaxel 6 mg/ml concentrate for solution for infusionHospira UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 18Document updated 23 March 2026

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