Answer
Combining lamivudine with cladribine is not recommended because lamivudine inhibits cladribine’s intracellular phosphorylation in vitro, potentially reducing cladribine’s clinical efficacy, with some clinical findings also supporting a possible interaction.
Sources for this answer
- Epivir Oral SolutionViiV Healthcare UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 45Document updated
Sources checked