Answer
Givinostat weakly inhibits the renal uptake transporter OCT2, and metformin is a sensitive OCT2 substrate for which small changes in plasma concentration may lead to serious toxicities, warranting close monitoring.
Sources for this answer
- Duvyzat 8.86 mg/mL oral suspensionITF Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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