Answer
Close INR monitoring is recommended when ledipasvir + sofosbuvir is used with vitamin K antagonists because liver function may change during treatment.
Sources for this answer
- Ledipasvir/Sofosbuvir Gilead 90 mg/400 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 6Document updated
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