Answer
Cladribine is not recommended with Combivir (lamivudine + zidovudine) because lamivudine inhibits cladribine’s intracellular phosphorylation in vitro, potentially reducing cladribine’s efficacy; some clinical findings also support a possible interaction.
Sources for this answer
- Combivir 150 mg/300 mg Film-coated TabletsViiV Healthcare UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 42Document updated
Sources checked