Answer
Caution is needed with peginterferon beta-1a because interferons can reduce hepatic cytochrome P450 enzyme activity, while some antiepileptics and antidepressants have a narrow therapeutic index and depend largely on this system for clearance.
Sources for this answer
- Plegridy solution for injection in pre-filled pen and syringeBiogen Idec Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 12Document updated
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