Answer
Caution is needed when nortriptyline hydrochloride is taken with methadone because of potential additive effects on the QT interval and an increased risk of serious cardiovascular effects.
Sources for this answer
- Nortriptyline 10mg Film-coated TabletsGlenmark Pharmaceuticals Europe Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
Sources checked