Answer
Caution is advised with azelastine hydrochloride/fluticasone propionate nasal spray because ketoconazole potently inhibits CYP3A4 and may increase systemic fluticasone propionate exposure, although studies showed only minor increases without notable reductions in serum cortisol.
Sources for this answer
- Flomister 137 micrograms / 50 micrograms per actuation nasal spray, suspensionStrides Pharma UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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