sofosbuvir · Medicine question

Why is carbamazepine contraindicated with sofosbuvir?

iatroX medicinesPublished 8 November 2026

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Carbamazepine is contraindicated with sofosbuvir because it strongly induces intestinal P-glycoprotein, significantly decreasing sofosbuvir plasma concentrations and potentially causing loss of Sovaldi efficacy.

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Sovaldi 400 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §4.3 Contraindications · Version 4Document updated 13 February 2024

Sources checked 8 November 2026

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