Answer
Sofosbuvir is converted inside cells into the active uridine analogue triphosphate GS-461203, which the hepatitis C virus NS5B RNA-dependent RNA polymerase incorporates into viral RNA, terminating the RNA chain and thereby inhibiting viral replication.
Sources for this answer
- Sovaldi 400 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated
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