Answer
Brivudine irreversibly inhibits DPD, significantly increasing fluorouracil injection exposure and potentially causing fatal toxicity, so at least four weeks must separate brivudine administration from starting fluorouracil treatment.
Sources for this answer
- Fluorouracil 25 mg/ml InjectionHospira UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 19Document updated
Sources checked