fluorouracil · Medicine question

How can fluorouracil injection affect prothrombin time and INR in patients taking warfarin?

Name: How can fluorouracil injection affect prothrombin time and INR in patients taking warfarin?
Published: 2026-11-08T01:48:14.724Z

iatroX medicinesPublished 8 November 2026

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Marked elevations of prothrombin time and INR have been reported in a few patients stabilised on warfarin after starting fluorouracil injection regimens.

Sources for this answer

Fluorouracil 25 mg/ml InjectionHospira UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 19Document updated 18 May 2026

Sources checked 8 November 2026

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