Answer
Mycophenolate mofetil’s metabolite MPA inhibits IMPDH and de novo guanosine nucleotide synthesis, on which T- and B-lymphocyte proliferation critically depends, whereas other cell types can use salvage pathways.
Sources for this answer
- Cellcept 250mg CapsulesRoche Products Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 41Document updated
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