Answer
The kidneys remove most amantadine unchanged. Reduced kidney function can cause accumulation and serious neurological toxicity, and severe renal disease is contraindicated.
Sources for this answer
- Amantadine hydrochloride 50 mg/5 ml Oral Solutionemc · SmPC Current selected SmPC · Version 1
- Amantadine hydrochloride 100mg capsulesemc · SmPC Current selected SmPC · Version 1