Answer
Imipramine hydrochloride requires extreme caution in people with epilepsy because tricyclic antidepressants lower the seizure threshold, and seizure occurrence appears to be dose dependent.
Sources for this answer
- Imipramine Hydrochloride 25mg/5ml Oral SolutionEssential Pharma Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 4Document updated
Sources checked