Answer
Combining spironolactone, a potassium-sparing diuretic, with potassium chloride 0.15%, sodium chloride 0.18% and glucose 4% infusion increases the risk of severe, potentially fatal hyperkalaemia, particularly when other risk factors for hyperkalaemia are present.
Sources for this answer
- Potassium Chloride 0.15 % w/v, Sodium Chloride 0.18 % w/v and Glucose 4% w/v, Solution for InfusionBaxter Healthcare Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
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