Answer
Clomipramine hydrochloride requires extreme caution in patients with epilepsy because tricyclic antidepressants lower the convulsion threshold, and seizures appear dose-dependent, so the recommended total daily dose must not be exceeded.
Sources for this answer
- Clomipramine 25 mg Capsules, HardViatris (formerly Mylan or Upjohn) · emc · SmPC §4.4 Special warnings and precautions for use · Version 2Document updated
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