Answer
Valproate in Epilim Chronosphere reduces lamotrigine metabolism and nearly doubles its mean half-life, which may increase lamotrigine toxicity, particularly serious skin rashes.
Sources for this answer
- Epilim Chronosphere MR 100 mg modified release granulesSANOFI · emc · SmPC §4.5 Interaction with other medicinal products · Version 36Document updated
Sources checked