Answer
Ritonavir strongly inhibits CYP3A4, potentially increasing exposure to Seretide Accuhaler’s fluticasone propionate (risking Cushing’s syndrome and adrenal suppression) and salmeterol (risking systemic effects); concomitant use should be avoided unless benefits outweigh the increased risks.
Sources for this answer
- Seretide 100, 250, 500 AccuhalerGlaxoSmithKline UK · emc · SmPC §4.5 Interaction with other medicinal products · Version 46Document updated
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