daunorubicin hydrochloride · Medicine question

Why can previous treatment with trastuzumab increase the risk of heart toxicity from daunorubicin hydrochloride?

iatroX medicinesPublished 8 November 2026

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Previous trastuzumab treatment may increase heart toxicity risk from daunorubicin hydrochloride because trastuzumab is cardiotoxic and has a long half-life, so increased risk may persist after trastuzumab is stopped.

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Daunorubicin 20mg Powder for InjectionZentiva · emc · SmPC §4.4 Special warnings and precautions for use · Version 7Document updated 19 March 2020

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