Answer
The transient male infertility and reduced pregnancy rates in female rodents seen with systemic fluorouracil are considered unlikely to be relevant to humans because absorption of active compounds after cutaneous application of Actikerall is very limited.
Sources for this answer
- Actikerall 5mg/g + 100mg/g Cutaneous SolutionAlmirall Limited · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 7Document updated
Sources checked