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Medicines naloxone hydrochloride + oxycodone hydrochlorideQuestion & answer

naloxone hydrochloride + oxycodone hydrochloride · Medicine question

Why are naloxone hydrochloride and oxycodone hydrochloride combined?

iatroX medicinesPublished 21 August 2026Reviewed 21 August 2026

The answer

Answer

Oxycodone provides opioid pain relief, while orally administered naloxone acts mainly in the bowel to oppose opioid-related bowel dysfunction.

Sources for this answer

Oxycodone hydrochloride/Naloxone hydrochloride 10 mg/5 mg prolonged-release tabletsemc · SmPC Current selected SmPC · Version 1

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The full medicine guide

naloxone hydrochloride + oxycodone hydrochloride

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