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Medicines naloxone hydrochloride + oxycodone hydrochlorideQuestion & answer

naloxone hydrochloride + oxycodone hydrochloride · Medicine question

Can naloxone hydrochloride + oxycodone hydrochloride tablets be crushed?

iatroX medicinesPublished 21 August 2026Reviewed 21 August 2026

The answer

Answer

No. Crushing, chewing or breaking the selected prolonged-release tablet can release oxycodone rapidly and cause a potentially fatal overdose.

Sources for this answer

Oxycodone hydrochloride/Naloxone hydrochloride 10 mg/5 mg prolonged-release tabletsemc · SmPC Current selected SmPC · Version 1

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The full medicine guide

naloxone hydrochloride + oxycodone hydrochloride

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