Answer
Strong enzyme inducers such as rifampicin, carbamazepine, phenytoin and phenobarbital can reduce exposure. St John’s wort can have the same effect.
Sources for this answer
- Apremilast 30 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- Otezla 10mg, 20mg, 30mg — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.