Answer
Yes. Depression, altered mood and suicidal thoughts or behaviour have been reported. New or worsening symptoms require prompt clinical review; immediate danger requires emergency help.
Sources for this answer
- Apremilast 30 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- Otezla 10mg, 20mg, 30mg — Current selected SmPCemc · Summary of Product Characteristics
- UK GovernmentUK Government · Reputable Web
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.