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Medicines ZanidatamabQuestion & answer

Zanidatamab · Medicine question

Which HER2 domains does zanidatamab bind to?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Zanidatamab simultaneously binds extracellular domains 2 and 4 on separate HER2 monomers (binding in trans).

Sources for this answer

Ziihera 300 mg powder for concentrate for solution for infusionJazz Pharmaceuticals Research UK Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated 24 June 2026

Sources checked 8 November 2026

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Zanidatamab

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