Answer
In vitro, CYP3A4 is the primary enzyme responsible for selumetinib oxidative metabolism, with CYP2C19, CYP2C9, CYP2E1 and CYP3A5 contributing to a lesser extent.
Sources for this answer
- Koselugo 10 mg hard capsulesAstraZeneca UK Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 8Document updated
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