Answer
CYP3A4 is the predominant enzyme responsible for selumetinib oxidative metabolism in vitro, with CYP2C19, CYP2C9, CYP2E1 and CYP3A5 contributing to a lesser extent.
Sources for this answer
- Koselugo 5 mg granules in capsule for openingAstraZeneca UK Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 1Document updated
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