Answer
In healthy adults, co-administration of rifampicin 600 mg daily for 8 days decreased selumetinib peak concentration (Cmax) by 26% and exposure (AUC) by 51%; concomitant use should be avoided.
Sources for this answer
- Koselugo 5 mg granules in capsule for openingAstraZeneca UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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