Answer
Mesalazine is metabolised pre-systemically by the intestinal mucosa and systemically in the liver, principally by NAT-1, to N-acetyl mesalazine (acetyl mesalazine), with some acetylation also occurring through colonic bacteria.
Sources for this answer
- Pentasa Mesalazine Enema, 1g /Mesalazine Ferring 1g Rectal SuspensionFerring Pharmaceuticals Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 20Document updated
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