Answer
Mesalazine’s therapeutic benefit appears to come from a local effect on inflamed intestinal tissue rather than a systemic effect, although its mechanism of action is not fully understood.
Sources for this answer
- Pentasa Mesalazine Enema, 1g /Mesalazine Ferring 1g Rectal SuspensionFerring Pharmaceuticals Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 20Document updated
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