When should alverine citrate + simeticone be discontinued because of elevated liver enzymes or jaundice?

Alverine citrate + simeticone (Simalvia) should be discontinued if hepatic aminotransferases exceed 3 times ULN and/or jaundice occurs; unexplained persistent nausea, decreased appetite, fatigue, vomiting, right upper abdominal pain, dark urine or pale faeces also require stopping, immediate reporting and immediate hepatic-function evaluation.