Answer
Hyperammonaemia associated with pegaspargase (Oncaspar) can cause often-transient nausea, vomiting, headache, dizziness and rash; severe cases can cause life-threatening or fatal encephalopathy with or without hepatic impairment, especially in older adults.
Sources for this answer
- Oncaspar 750 U/ml powder for solution for injection/infusionServier Laboratories Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 8Document updated
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