Answer
Giving pegaspargase (Oncaspar) before vincristine may increase vincristine’s neurotoxicity, so vincristine should be given at least 12 hours before Oncaspar to minimise toxicity.
Sources for this answer
- Oncaspar 750 U/ml powder for solution for injection/infusionServier Laboratories Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated
Sources checked