Answer
Hydromorphone hydrochloride can cause central sleep apnoea and sleep-related hypoxemia and worsen pre-existing sleep apnoea, with central sleep apnoea risk increasing dose-dependently; reducing the total opioid dosage should be considered if central sleep apnoea develops.
Sources for this answer
- Palladone 2 mg/ml solution for injection or infusionNapp Pharmaceuticals Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 12Document updated
Sources checked