Answer
Hydromorphone hydrochloride has low plasma protein binding (less than 10%), remaining constant across plasma concentrations from 2.46 to 81.99 ng/ml, with the latter only very rarely achieved at very high doses.
Sources for this answer
- Palladone 2 mg/ml solution for injection or infusionNapp Pharmaceuticals Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 12Document updated
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