What skin and bone abnormalities have been reported in children receiving high doses of mercaptamine bitartrate and other cysteamine preparations?

With Cystagon (mercaptamine bitartrate) and other cysteamine preparations, chronic high doses, mostly above 1.95 g/m²/day, have been linked in children to Ehlers–Danlos-like syndrome, elbow vascular disorders, vascular proliferation, skin striae, genu valgum, leg pain, hyperextensive joints, osteopenia, compression fractures and scoliosis; histology suggested angioendotheliomatosis where performed.