melphalan hydrochloride · Medicine question

What serious interaction has occurred when nalidixic acid was given with high-dose intravenous melphalan hydrochloride in children?

Name: What serious interaction has occurred when nalidixic acid was given with high-dose intravenous melphalan hydrochloride in children?
Published: 2026-11-08T01:56:50.525Z

iatroX medicinesPublished 8 November 2026

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Nalidixic acid given with high-dose intravenous melphalan hydrochloride has caused deaths in children due to haemorrhagic enterocolitis.

Sources for this answer

Melphalan 50 mg Powder and Solvent for Solution for Injection/InfusionAspen · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated 28 March 2025

Sources checked 8 November 2026

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