Answer
Melphalan hydrochloride can increase the risk of secondary acute myeloid leukaemia, with frequency unknown, and has been reported to be leukaemogenic especially in older patients after prolonged combination therapy and radiotherapy.
Sources for this answer
- Melphalan 50 mg Powder and Solvent for Solution for Injection/InfusionAspen · emc · SmPC §4.8 Undesirable effects · Version 8Document updated
- Melphalan 50 mg Powder and Solvent for Solution for Injection/Infusion