Answer
Taking naloxone hydrochloride + oxycodone hydrochloride with benzodiazepines increases the risk of sedation, respiratory depression, coma and death through additive central nervous system depression; the dose and duration of combined use should be limited.
Sources for this answer
- Oxycodone hydrochloride/Naloxone hydrochloride 10 mg/5 mg prolonged-release tabletsKrka UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated
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