Answer
Yes, naloxone hydrochloride + oxycodone hydrochloride can cause sleep-related breathing disorders, including central sleep apnoea and sleep-related hypoxemia; central sleep apnoea risk increases with opioid dose, and reducing the total opioid dose should be considered if it occurs.
Sources for this answer
- Oxycodone hydrochloride/Naloxone hydrochloride 10 mg/5 mg prolonged-release tabletsKrka UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 1Document updated
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