Answer
Pizotifen malate requires caution in patients with kidney impairment and dosage adjustment may be necessary, because accumulation of inactive metabolites potentially leading to accumulation of the parent drug cannot be excluded, and no specific pharmacokinetic studies have been conducted in these patients.
Sources for this answer
- Pizotifen 0.5 mg TabletsSovereign Medical · emc · SmPC §5.2 Pharmacokinetic properties · Version 1Document updated
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