Answer
Pizotifen malate helps prevent migraine by blocking serotonin- and histamine-induced increases in cranial vessel permeability, maintaining normal pain thresholds, and inhibiting platelet serotonin reuptake to maintain plasma serotonin and prevent loss of tone and passive widening of extracranial arteries.
Sources for this answer
- Pizotifen 0.5 mg TabletsSovereign Medical · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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