Answer
Sodium thiosulfate’s protection against cisplatin-induced hearing damage is not fully understood but may involve increasing endogenous antioxidants, inhibiting intracellular oxidative stress, and direct interaction between cisplatin and sodium thiosulfate’s thiol group to produce inactive platinum species.
Sources for this answer
- Pedmarqsi 80 mg/mL solution for infusionNorgine Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated
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