What joint complication has been reported with postoperative continuous intra-articular local anaesthetic infusions, for which bupivacaine hydrochloride is not approved?

Chondrolysis has been reported after postoperative continuous intra-articular local anaesthetic infusions, mostly involving the shoulder joint, although causality has not been established; continuous intra-articular infusion is not an approved indication for bupivacaine hydrochloride.