Glucarpidase · Medicine question

What is Voraxaze (glucarpidase) indicated for?

iatroX medicinesPublished 8 November 2026

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Voraxaze (glucarpidase) is indicated to reduce toxic plasma methotrexate concentrations in adults and children aged 28 days and older with delayed methotrexate elimination.

Sources for this answer

VoraxazeSERB · emc · SmPC §4.1 Therapeutic Indications · Version 1Document updated 2 June 2026

Sources checked 8 November 2026

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By what route and over how long is Voraxaze (glucarpidase) administered?What solution and volume are used to reconstitute each vial of Voraxaze (glucarpidase)?How can glucarpidase affect folinic acid concentrations?How does glucarpidase break down methotrexate?Is glucarpidase known to pass into human breast milk?What is known about the safety of glucarpidase during pregnancy?

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