Answer
Primidone’s precise anticonvulsant mechanism is unknown, but neuronal membrane effects, particularly altered ionic fluxes, likely play a fundamental role; the relative contributions of primidone and its main metabolites, phenobarbital and phenylethylmalonamide (PEMA), to the clinical anticonvulsant effect are not firmly established.
Sources for this answer
- PRIMIDONE SERB 250mg tabletSERB · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated
Sources checked