primidone · Medicine question

Can primidone cause megaloblastic anaemia?

iatroX medicinesPublished 8 November 2026

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Primidone can exceptionally cause megaloblastic anaemia requiring discontinuation of primidone, and this condition may respond to folic acid and/or vitamin B12.

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PRIMIDONE SERB 250mg tabletSERB · emc · SmPC §4.4 Special warnings and precautions for use · Version 10Document updated 27 October 2026

Sources checked 8 November 2026

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