Answer
Hyperalgesia during long-term oxycodone hydrochloride treatment is increased pain that tends to be more diffuse and less clearly defined than pre-existing pain, may differ from disease-progression or tolerance-related breakthrough pain, and may resolve with opioid dose reduction.
Sources for this answer
- OxyNorm liquid 1 mg/ml oral solutionNapp Pharmaceuticals Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 26Document updated
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